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PRF Treatment: The Ultimate Guide

Updated: Feb 12

PRF Treatment - Selphyl

PRF treatment has gained immense popularity in recent years due to its remarkable benefits. This revolutionary technique utilizes the patient's own body growth factors and blood to promote tissue healing support. In this blog post, we will describe PRF therapy, explore the top six benefits of PRF treatment, and what to expect from the entire process.

What is Platelet Rich Fibrin (PRF) Therapy?

Platelet-rich plasma treatment is an innovative and holistic therapy that harnesses the healing power of your own blood to promote tissue healing support. If you're searching for a safe and natural approach to address various conditions or enhance your overall well-being, PRF treatment might be the solution you've been seeking.

During a PRF treatment session, a small sample of your blood is extracted and processed to separate the platelets and fibrin—the essential components responsible for healing and tissue repair support. This concentrated PRF is then skillfully applied or injected into the targeted area, releasing a powerful blend of growth factors and cytokines that jumpstart your body's natural healing mechanisms.

The beauty of PRF treatment lies in its simplicity and effectiveness. By utilizing your body's own resources, PRF treatment offers a holistic alternative to conventional therapies, reducing the risk of allergic reactions or adverse side effects.

Whether you're seeking to accelerate the healing of an injury, improve skin texture and skin tone, promote hair growth, or enhance dental procedures, PRF treatment has shown promising results in a wide range of applications. Join us as we explore the remarkable benefits and applications of PRF treatment, empowering you to make informed decisions about your health and well-being.

What Are the 6 Top Benefits of Platelet Rich Fibrin (PRF) Therapy?

PRF therapy has emerged as a game-changer in the field of tissue healing. With its unique advantages, this advanced therapy surpasses conventional treatments, offering patients a superior option for naturally improved outcomes. Here are the top 6 PRF therapy benefits:

1. Accelerated Healing Process:

PRF therapy accelerates the healing process by harnessing the power of your body's own platelets and growth factors. Compared to conventional therapies, PRF therapy promotes faster tissue repair, reduces recovery time, and enhances overall healing outcomes.

2. Reduced Risk of Allergic Reactions:

Unlike conventional therapies that often involve synthetic substances or medications or other blood components, PRF therapy uses your own blood. This personalized approach minimizes the risk of allergic reactions or adverse side effects, ensuring a safer and more comfortable treatment experience.

3. Enhanced Tissue Healing Support:

While Platelet-Rich Fibrin (PRF) itself does not contain stem cells, it does contain a rich concentration of growth factors, cytokines, and bioactive proteins that can influence the behavior of existing stem cells in the treatment area. PRF therapy does not directly introduce exogenous mesenchymal stem cells (MSCs) into the body, it can influence and interact with the existing MSCs present in the treatment area.

This natural approach promotes the formation of new blood vessels and the body’s growth factors, facilitates the wound-healing process, accelerates collagen production, and results in more robust and sustainable tissue healing support.

4. Long-Lasting Results:

Unlike some other treatment modalities that offer temporary relief or superficial improvements, PRF therapy targets the underlying cause of the condition, leading to more sustainable and long-lasting results. Through its natural and personalized approach, PRF therapy stimulates the body's healing mechanisms and stimulates collagen production. By supporting the body's innate healing abilities, PRF therapy offers the potential for sustained improvements and an enhanced quality of life.

For example, collagen, a crucial protein for skin elasticity and tissue support, enhances skin quality and skin tightening, reduces acne scars, and improves the structural integrity of the treated area over an extended period.

5. Versatile Applications:

PRF therapy showcases its versatility across various medical and aesthetic fields. From orthopedics to dentistry and dermatology, PRF therapy offers successful outcomes in accelerating the wound healing of tendon injuries, and improving post-surgical recovery, among other applications.

6. Minimized Downtime:

Compared to invasive procedures or extensive recovery periods associated with conventional therapies, PRF therapy typically involves minimal downtime. As an outpatient treatment, PRF therapy allows patients to resume their regular activities sooner, minimizing disruption to their daily lives.

How To Be Prepared for Platelet-Rich Fibrin (PRF) Therapy

Platelet-Rich Fibrin (PRF) therapy is a cutting-edge treatment that utilizes the healing properties of your own blood to promote tissue repair. If you're considering PRF therapy, it's important to adequately prepare for the procedure to maximize its benefits and ensure a smooth recovery. Here are some essential steps to help you prepare for PRF therapy and enhance the overall effectiveness of your treatment.

1. Consult with a Skilled Practitioner:

The first step in preparing for PRF therapy is to schedule a consultation with a skilled and experienced healthcare practitioner. They will evaluate your condition, discuss your medical history, and determine if you are suitable for PRF therapy. During this consultation, it's important to ask any questions you may have and address any concerns.

Inform your healthcare practitioner about any medications you are currently taking, including over-the-counter drugs, supplements, and herbal remedies. Certain medications, such as blood thinners, may need to be adjusted or temporarily discontinued before the PRF therapy procedure. Additionally, disclose any underlying medical conditions you have, as this information can help your practitioner tailor the treatment to your specific needs.

PRF Treatment - Selphyl

2. Follow Pre-Treatment Guidelines:

Your healthcare practitioner will provide you with specific pre-treatment guidelines to follow in the days leading up to your PRF therapy. These guidelines may include instructions to avoid smoking, alcohol, and certain medications that can interfere with the healing process. Make sure to carefully adhere to these guidelines to optimize your body's response to the treatment.

In the days leading up to your PRF therapy, ensure you stay adequately hydrated. Drinking plenty of water helps optimize your blood circulation and overall health, enhancing the efficacy of the treatment. Hydration is particularly important since PRF therapy utilizes the healing components within your blood to accelerate the healing process.

3. Dress Comfortably and Bring the Necessary Items:

On the day of your PRF therapy, wear comfortable and loose-fitting clothing to ensure ease of access to the treatment area. Depending on the specific treatment, you may need to bring additional items such as a change of clothes, a hat, or a scarf to protect the treated area post-procedure. Your healthcare practitioner will inform you of any specific requirements beforehand.

4. Arrange for Transportation:

PRF therapy is generally a minimally invasive procedure with minimal downtime. However, depending on the treatment area and your individual response, you may experience some temporary discomfort or mild sedation during the procedure. Many PRF treatments are performed under local anesthesia only, but some patients prefer to undergo light sedation (not general anesthesia) to minimize anxiety. To ensure your safety, it is recommended to arrange for transportation to and from the clinic on the day of the treatment.

PRF Treatment Safety - What to Expect

When considering any medical procedure, safety is a top priority for patients. Platelet-Rich Fibrin (PRF) treatment is a safe and innovative therapy that utilizes your body's natural healing properties. Here are some safety aspects of PRF treatment and what you should expect during the procedure.

  • Safety of PRF Treatment:

PRF treatment is considered a safe and well-tolerated procedure when performed by a qualified healthcare professional. The therapy utilizes your own blood, eliminating the risk of allergic reactions or transmission of diseases. As PRF is derived from a simple blood draw, the chances of adverse reactions or complications are significantly reduced.

PRF Treatment - Selphyl

  • Sterile Procedure:

During PRF treatment, the healthcare practitioner follows strict protocols to maintain a sterile environment. This includes using sterile instruments, wearing gloves, and ensuring the treatment area is thoroughly cleaned. By adhering to these protocols, the risk of infection or other complications is minimized.

  • Minimal Discomfort:

PRF treatment is typically associated with minimal discomfort. Before the procedure, your healthcare practitioner may administer a local anesthetic to numb the treatment area, ensuring your comfort throughout the process. While you may experience mild soreness or swelling following getting your blood drawn and the PRF injections, these symptoms are temporary and generally subside quickly.

  • Personalized Treatment Plan:

Each patient's condition is unique, and PRF treatment is tailored to meet individual needs. During your consultation, your healthcare practitioner will evaluate your specific requirements and develop a personalized treatment plan. They will discuss the expected outcomes, potential risks, and any necessary precautions to ensure you have a clear understanding of the procedure.

  • Recovery and Follow-up Care:

Following PRF treatment, most patients can resume their normal activities immediately. However, your healthcare practitioner may provide specific instructions regarding post-treatment care, such as avoiding vigorous physical activities, applying ice packs, or taking prescribed medications. It's important to follow these instructions to support the healing process and achieve optimal results.

  • Monitoring and Follow-up Visits:

After your PRF treatment, your healthcare practitioner may schedule follow-up visits to monitor your progress. These visits allow them to assess your healing, address any concerns, and make any necessary adjustments to your treatment plan. Regular communication with your healthcare provider is essential to ensure a smooth recovery and maximize the benefits of PRF therapy.

What’s the difference between PRF and PRFM?

PRF (Platelet-Rich Fibrin) and PRFM (Platelet-Rich Fibrin Matrix) are both tissue healing support therapies that utilize the healing properties of platelets and growth factors derived from the patient's own blood. While they share similarities, there are some differences between the two.

PRF (Platelet-Rich Fibrin):

PRF is a concentrated form of platelet-rich plasma (PRP) that is processed to create a fibrin matrix. It is derived by collecting a small amount of the patient's blood, which is then centrifuged to separate the platelets, growth factors, and other beneficial components from the rest of the blood. The resulting PRF is a gel-like substance that contains a high concentration of platelets, leukocytes (white blood cells), and cytokines.

PRF has several distinct characteristics and advantages:

  1. Fibrin Matrix: PRF forms a fibrin matrix during the centrifugation process. This matrix helps to support the platelets and other growth factors, providing a scaffold for tissue and wound healing support.

  2. Slow Release of Growth Factors: PRF releases growth factors gradually over a longer period compared to PRP. This sustained release can promote prolonged healing support.

  3. Rich in Leukocytes: PRF contains a higher concentration of leukocytes compared to PRP. Leukocytes have immune-modulatory properties and can contribute to the regulation of inflammation and the immune response during the healing process.

PRFM (Platelet-Rich Fibrin Matrix):

PRFM is an advanced version of PRF that undergoes additional processing to further concentrate the platelets and growth factors. The process involves the addition of an activating agent, such as calcium chloride, which triggers the release of more growth factors and enhances the platelet concentration.

Key features of PRFM include:

  1. Higher Platelet Concentration: PRFM typically contains a higher concentration of platelets compared to PRF. The increased platelet concentration may offer more potent effects.

  2. Liquid Form: Unlike PRF, PRFM is usually prepared in a liquid form. This allows for more precise application and delivery to the treatment area, including injections and localized treatments.

  3. Shorter Activation Time: PRFM has a faster activation time compared to PRF. The activating agent speeds up the release of growth factors.

It's worth noting that the terminology and preparation techniques for PRF and PRFM can vary among healthcare practitioners and researchers. The specific protocols and applications may differ depending on the desired therapeutic goals and the preferences of the healthcare professional.

In summary, both PRF and PRFM utilize the healing support properties of platelets and growth factors derived from the patient's own blood. PRF forms a fibrin matrix and releases growth factors gradually, while PRFM has a higher platelet concentration and shorter activation time. The choice between PRF and PRFM depends on the specific needs and preferences of the patient, as well as the recommendations of the healthcare professional.


PRF therapy offers remarkable benefits for enhanced skin quality and wound healing. With its natural and safe approach, it has become an increasingly popular treatment option across various medical fields. By understanding the basics of PRF therapy, including its benefits, safety considerations, and what to expect during the procedure, you can make an informed decision about whether this innovative therapy is right for you. Consult with a qualified healthcare professional to explore the potential of PRF therapy in enhancing your healing and well-being.

Selphyl® next-generation platelet-rich fibrin treatment (PRFM) kits are designed to produce safe and rapid preparation of PRP devoid of contaminating red blood cells and white blood cells while delivering a higher platelet concentration. Our proprietary gel separator design is one of the key advantages of the SELPHYL® System. Contact us today to elevate your practice and provide the most advanced therapies like platelet-rich fibrin matrix (PRFM) to your patients.

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