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PRP Microneedling: Benefits, Side Effects, FAQs, and More

Updated: Feb 12

Naheed Ali, MD, PhD

If you've been looking for a game-changing solution to treat your skin troubles and revitalize your complexion, you're not alone. Within the ever-evolving field of aesthetics, platelet-rich plasma (PRP) microneedling is a therapy that has become popular due to its potential outcomes. We’ll go deeper into the realm of PRP microneedling in this expert guide, examining its possible competitive edges and the reasons it has grown in popularity as a skin-rejuvenating and revitalizing treatment.

What is PRP Microneedling?

PRP microneedling, a cutting-edge cosmetic procedure, synergizes the regenerative potential of Platelet-Rich Plasma (PRP) with the established advantages of microneedling. PRP is a particular fraction of your blood that has a concentration of platelets that is often double the average amount found in whole blood. Importantly, PRP ought to ideally be free of red blood cells and white blood cells, since their presence might have counterproductive inflammatory and catabolic effects.

PRP microneedling works as follows: a small sample of your blood is taken, usually from your arm, and then processed to separate the golden, straw-like PRP from other blood components, thus ensuring its purity and efficacy. The PRP is then applied topically or injected into the treatment area. The microneedling aspect involves a specialized device fitted with fine, sterile needles to create controlled micro-injuries on the skin's surface. These micro-injuries stimulate your body's natural healing response and kickstart the production of collagen, a vital protein responsible for skin elasticity and firmness.

PRP Microneedling - Selphyl

Benefits of PRP Microneedling

Let's determine the scientifically backed benefits of this treatment and ascertain how it could be a game-changer for various skin concerns.

1. Reducing wrinkles and fine lines

You may find it reassuring to know that the quest for smoother, younger-looking skin has a scientifically backed ally in PRP microneedling. Consider a study involving 113 patients who underwent an average of 1.5 sessions over three years. They reported substantial improvements in the smoothness of their skin and firmness—what is medically referred to as wrinkle effacement and skin laxity—based on satisfaction scores from both the patients and independent observers after 12 months. This research points to the enduring effects of PRP microneedling, which can be crucial when you are investing in long-term skin health. [1] [2]

2. Improving skin texture and elasticity

In conjunction with the previous study, the results of another study in which subjects had six microneedling treatments at two-week intervals were similarly notable. Those with moderate signs of aging and certain skin types witnessed not just visible improvements in their skin's appearance but also an underlying rejuvenation. There was a significant increase in the building blocks of your skin—specifically types of collagen and elastin—which are essential for maintaining the skin's structure and elasticity. [3]

3. Diminishing the appearance of acne scars

The battle against acne scars can often seem endless, but PRP microneedling provides a viable strategy to reduce their prominence. The treatment's effectiveness on acne scars is twofold: firstly, the microneedling breaks down old scar tissue and prompts the skin to generate new cells. Secondly, the PRP emancipates growth factors that further stimulate the healing process, leading to the production of new, healthy skin cells to replace scar tissue.

In a study comparing microneedling with PRP against Vitamin C, the improved response with PRP indicates that the biological components in your blood can be more powerful in healing and tissue regeneration than in some select topical treatments. While Vitamin C has its place, particularly in managing discoloration, PRP targets the underlying facets of the skin, making it particularly effective for indented or atrophic scars. [4]

4. Promoting hair growth

One of the most interesting advances in hair restoration therapy is the impact of PRP microneedling on encouraging hair growth. PRP is injected directly into the scalp, where it works to regenerate the hair follicles. The growth factors in PRP can achieve this by extending the growth phase of the hair cycle, increasing follicle size, and stimulating stem cells around the follicles, all leading to thicker, fuller hair. In at least four sessions, individuals receiving PRP microneedling for androgenetic alopecia (male or female pattern baldness) reported improvement, according to research. [5]

Potential Side Effects of PRP Microneedling

When considering PRP microneedling, acknowledging the potential side effects is just as crucial as understanding the benefits. It's a generally safe procedure, but like with any medical intervention, there are potential risks at hand.

1. Redness and swelling

Following your PRP microneedling procedure, you may notice some redness and swelling. Consider this as your skin's natural reaction to the minuscule holes that the microneedling procedure has generated; it signifies that your body's healing processes are beginning to take over. This redness and swelling are generally harmless, similar to a sunburn, and they normally go away in a few days.

2. Bruising

Bruising is another side effect you might notice. It's not as common as redness and swelling, but it can occur, particularly in areas where your skin may be more delicate or if you're prone to bruising. They are usually small and fade within a week or so.

3. Temporary discomfort

Some level of discomfort during and after the PRP microneedling procedure is normal. You may feel a sensation akin to a mild sunburn after the session. While the treatment area heals, there might be some tightness or sensitivity to the touch, but this is usually short-lived.

PRP Microneedling vs. Other Skin Rejuvenation Treatments

PRP microneedling—unlike laser treatments, chemical peels, dermabrasion, or Botox—boosts the body's natural repair functions rather than just removing skin layers or paralyzing muscles. Using platelet-rich plasma fosters stronger collagen and elastin production, enhancing skin texture with minimal risk, less downtime, and more lasting results, offering a gentler yet effective anti-aging alternative.

PRP Microneedling - Selphyl

Preparation for PRP Microneedling Treatment

Your journey to improved skin health with PRP microneedling begins well before you sit down for your session. Making the necessary preparations can help reduce any negative effects and optimize outcomes.

One week before treatment

You will be advised to stop taking certain drugs and supplements, such as aspirin, ibuprofen, and vitamin E, a week before your consultation since they may increase the risk of bruising and bleeding. To guarantee that your skin is in the best possible condition for the treatment, you may also be urged to steer clear of retinoid products, which might irritate the skin.

Day of the treatment

You should avoid wearing any makeup, moisturizers, or sunscreen on the day of your treatment. Before the visit, your physician may purvey special instructions on how to cleanse your face. If you think that any side effects could impair your ability to drive, it's a good idea to make plans for someone to drive you home, but rest assured that this is not typical.

Post treatment

It's critical to follow your provider's aftercare recommendations following your session to aid in the healing process. Using a mild cleanser, applying specific post-procedure products, and avoiding direct sun exposure are all examples of precautions. You'll be told to avoid cosmetics and strenuous exercise for a few days to allow your skin to heal without extra irritation or sweat-induced bacteria. Staying hydrated is also essential for a quick recovery.

PRP Microneedling FAQs

At this point, you're certain to have a few questions. Let's go over some of the most frequently asked questions to give you a better idea of what to anticipate from this therapy.

1. The number of sessions typically required

The answer depends on your skin issues and objectives. On average, you should anticipate having 3–6 sessions spaced 4–6 weeks apart. Some studies, such as the one on androgenetic alopecia, imply that a minimum of four sessions can result in considerable benefits.

2. The expected downtime after treatment

When compared to more invasive treatments, the downtime following PRP microneedling is minimal. In general, you might expect some redness and swelling for 24 to 48 hours after treatment. Most people can resume their usual routines within a day.

3. The cost of PRP microneedling

PRP microneedling rates vary by geography, provider experience, and frequency of sessions and can range from hundreds to thousands of dollars. As it’s considered an aesthetic procedure, it’s also not covered by insurance. It's advisable to discuss costs with your provider ahead of time to receive an exact quote based on your particular treatment plan.

4. The suitability of PRP microneedling for different skin types

PRP microneedling may be used on a variety of skin types; however, it is critical to discuss this with your skincare expert thoroughly, since some skin issues might warrant a different strategy. If you have active acne or certain skin infections, for example, you may need to wait until these are resolved before proceeding with microneedling.


You've learned about the many advantages of PRP microneedling, a groundbreaking skin rejuvenation therapy that taps into your body's natural healing ability.

Your skin is unique, and PRP microneedling may be the answer for individuals looking to improve their skin's inherent beauty. If you're unsure if this therapy is the right therapy for you, it is best to visit a skilled dermatologist or aesthetic practitioner. They will provide you with individualized counseling aligned with your unique skin type, issues, and aesthetic objectives. It is also recommended to consult a practitioner before beginning any type of treatment to understand your body’s needs and ensure your health.

About the Author

Dr. Ali is a medical journalist and copywriter.


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