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PRF Under Eyes: A Critical Consideration of Benefits

Recently, the utilization of platelet-rich fibrin (PRF) for under-eye treatment has garnered notable attention within the medical community, particularly among practitioners specializing in cosmetic medicine and dermatologic surgery. This white paper explores the technical aspects, clinical benefits, and safety considerations of employing PRF under the eyes. 



What is PRF for under-eyes?


Platelet-rich fibrin (PRF) is a new type of platelet concentrate that is entirely autologous and prepared without any anticoagulants using low-speed centrifugation. This process preserves a dense array of growth factors within a three-dimensional fibrin matrix enriched with high concentrations of fibrin and other host immune cells [1-3]. PRF is theorized to enhance periorbital aesthetics in under-eye area treatments by modulating soft tissue properties, specifically stimulating collagen synthesis and promoting angiogenesis [1][2][4]. Although preliminary studies indicate improvements in dermal quality, further clinical validation is needed to confirm long-term outcomes and standardize protocols. 

From a mechanistic perspective, PRF in the periorbital region utilizes growth factors like platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-β) to stimulate fibroblast activity and enhance extracellular matrix deposition [1][5]. Its efficacy depends on patient-specific factors, such as baseline collagen density, skin elasticity, periorbital atrophy, and technical parameters, including centrifugation protocol, injection technique, and dosage [4][6]. Unlike platelet-rich plasma (PRP), which also harnesses autologous growth factors, PRF offers a sustained release of bioactive components that may enhance collagen production [1]. Consequently, choosing PRF for under-eye treatment should be based on a thorough assessment of the patient's anatomical characteristics. 


The Role of the Periorbital Area in Making the Face Look Olde


The periorbital area is highly susceptible to age-related changes, as evidenced by skin laxity, thinning, and the formation of dark circles. Histological studies have established that reduced collagen and elastin production, along with loss of skin thickness and dermal integrity and skin cells, are the primary forces behind the aged appearance in the under-eye area [3][6][7].


Dark Circles and Collagen Production

Dark circles typically result from vascular congestion, melanin deposition, and atrophy of subcutaneous fat [7][8]. PRF under-eye therapy has been postulated to correct these by stimulating collagen synthesis and enhancing microcirculation. The fibrin matrix acts as a scaffold for cell growth and controls the inflammatory processes inherent in skin repair [5]. Most patients undergoing PRF under-eye treatment experience reduced dark circles, improved skin quality, and smoother skin.


The Emergence of Eye Injections in the Cosmetic Sphere

The introduction of autologous blood products in aesthetic medicine has transformed approaches to enhancing body appearance, promoting a refreshed and reinvigorated look. The shift from synthetic fillers to biologically derived agents like PRF underscores a broader trend toward treatments that harness the body’s intrinsic healing mechanisms to achieve a youthful appearance. Historically, the use of eye injections was dominated by synthetic fillers and neuromodulators [6]; however, emerging data indicate that autologous treatments may offer improved biocompatibility and a reduced risk profile [1][9]. For instance, while platelet-rich plasma (PRP) tear trough procedures have gained popularity, PRF for the under-eye area presents a novel alternative with potential advantages in durability, eye fullness, and restorative outcomes.


Benefits of PRF Under-Eye Treatment

The benefits of using PRF in the under-eye region extend beyond simple volumization and can be optimized through a customized treatment plan. They include:

  • Increased Collagen Synthesis: The growth factors released from PRF stimulate collagen production, and their sustained release further promotes fibroblast proliferation, leading to a denser dermis, improved skin quality, and a more rested appearance [1][10].

  • Improved Skin Texture: PRF modulates an inflammatory reaction and causes tissue remodeling, leading to a smoother, refreshed appearance and periorbital skin contour [10].

  • Minimal Downtime: As an autologous product, PRF minimizes the risk of inducing allergic reactions and adverse events, thereby reducing post-procedural recovery time [1][10].

  • Long-term Clinical Efficacy: Early evidence indicates that PRF for the under-eye area, including the improvement in dark circles and tear trough appearance, persists over extended periods. Medical personnel and patients alike often inquire, for example, about how long it lasts under the eyes, and current literature indicates that the effects can be observed for several months following treatment [1][3][10].


PRF for Under Eyes FAQ


Does PRF work for the under-eyes?

Clinical studies and observational data suggest that PRF can enhance the periorbital aesthetic by stimulating collagen production and improving tissue quality. When applied precisely, PRF under-eye treatment can lead to measurable improvements in skin texture and volume. However, treatment efficacy depends on several factors, including the patient's skin condition, technique, and the specific centrifugation protocol employed [4]. 


How long does PRF last under the eyes?

The longevity of PRF for the under-eye area is a frequently queried topic among clinicians. Data derived from early clinical trials indicate that the effects of PRF, including improved collagen synthesis and volumetric restoration, may persist for several months [1][3][10]. The sustained-release mechanism inherent to the fibrin matrix is to extend the period of clinical efficacy beyond that of conventional PRP treatments. Nevertheless, further longitudinal studies are necessary to establish definitive duration parameters. 


How much does PRF under the eyes cost?

When discussing the economic aspects of PRF under-eye treatment, it is essential to contextualize the discussion within a framework of clinical efficacy and procedural precision. While cost is a relevant factor, emphasis should be placed on the technique’s potential and ability to reduce long-term treatment requirements. Medical personnel should critically evaluate cost considerations in the context of clinical outcomes and patient safety rather than presenting direct cost estimates to consumers. 


Can PRF go wrong?

As with any invasive procedure, administering PRF under the eyes carries inherent risks. Complications, though rare, may include infection, eye swelling, unintended tissue reaction, or suboptimal aesthetic outcomes [3][10]. The risk profile is mitigated by adherence to rigorous aseptic techniques and a thorough understanding of periorbital anatomy [9]. It is imperative to counsel patients regarding the potential for adverse events and ensure that informed consent is obtained before treatment. 


About the author: Dr. Ali is a medical journalist and copywriter.


References

  1. Pavlovic, V., Ciric, M., Jovanovic, V., Trandafilovic, M., & Stojanovic, P. (2021). Platelet-rich fibrin: Basics of biological actions and protocol modifications. Open Medicine (Warsaw, Poland), 16(1), 446–454. [DOI] [PubMed] [PMC free article] 

  2. Choukroun, J., & Ghanaati, S. (2018). Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society, 44(1), 87–95. [DOI] [PubMed] [PMC free article]

  3. Nagaja, S. A., John, R. S., G, S., Kumar, S. P., & Krishnan, M. (2024). Injectable platelet-rich fibrin and hyaluronic acid mesotherapy for management of actinic elastosis of lower eyelids: A case series. Cureus, 16(9), e68429. [DOI] [PubMed] [PMC free article]

  4. Mihaylova, Z., Mitev, V., Stanimirov, P., Isaeva, A., Gateva, N., & Ishkitiev, N. (2017). Use of platelet concentrates in oral and maxillofacial surgery: an overview. Acta Odontologica Scandinavica, 75(1), 1–11. [DOI] [PubMed]

  5. Dashore, S., Chouhan, K., Nanda, S., & Sharma, A. (2021). Platelet-rich fibrin, preparation and use in Dermatology. Indian Dermatology Online Journal, 12(Suppl 1), S55–S65. [DOI] [PubMed] [PMC free article]

  6. Davies C, Miron RJ. Autolougous platelet concentrates in esthetic medicine. Periodontol 2000. 2025;97(1):363-419. [DOI] [PubMed] [PMC free article]

  7. Vrcek, I., Ozgur, O., & Nakra, T. (2016). Infraorbital dark circles: A review of the pathogenesis, evaluation and treatment. Journal of Cutaneous and Aesthetic Surgery, 9(2), 65–72. [DOI] [PubMed] [PMC free article]

  8. Matsui, M. S., Schalka, S., Vanderover, G., Fthenakis, C. G., Christopher, J., Bombarda, P. C. P., Bueno, J. R., Viscomi, B. L. I., & Bombarda Júnior, M. S. (2015b). Physiological and lifestyle factors contributing to risk and severity of peri-orbital dark circles in the Brazilian population. Anais Brasileiros de Dermatologia, 90(4), 494–503. [DOI] [PubMed] [PMC free article]

  9. Mahmoodabadi, R. A., Golafshan, H. A., Pezeshkian, F., Shahriarirad, R., & Namazi, M. R. (2023). Evaluation of the effect of platelet-rich fibrin matrix in the correction of periorbital wrinkles: An experimental clinical trial. Dermatology Practical & Conceptual, 13(1), e2023050. [DOI] [PubMed] [PMC free article]

  10. Anitua, E., Pino, A., & Orive, G. (2016). Plasma rich in growth factors promotes dermal fibroblast proliferation, migration and biosynthetic activity. Journal of Wound Care, 25(11), 680–687. [DOI] [PubMed]

 
 
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