top of page
  • Selphyl Team

PRF vs PRP vs PRFM: What’s The Difference and Which One Is The Best?

One of the easiest ways to differentiate between these therapies is to understand that PRP (Platelet-Rich Plasma) was the original breakthrough, becoming widely used in the early 2000s. This was followed by the adoption of PRF (Platelet-Rich Fibrin) in the late 2000s and early 2010s. PRFM (Platelet-Rich Fibrin Matrix), the most recent development, gained popularity in the 2010s. These platelet-rich therapies have been progressively refined to optimize their potential and have found applications in various medical fields. Let’s dive into some more detailed information about these incredible therapies.

PRP Therapy: The Essential Information

What is PRP (Platelet-Rich Plasma)?

PRP, or Platelet-Rich Plasma, is a therapy that utilizes the patient's own blood. By drawing a small amount of blood and separating the platelets from other components, a concentrated plasma rich in growth factors is obtained. These growth factors help stimulate tissue healing support.

How does PRP treatment work?

When Platelet-Rich Plasma is injected into an injured area, the concentrated platelets release growth factors that initiate the body's natural wound-healing process. These growth factors promote cell proliferation, collagen production, and blood vessel formation, enhancing tissue repair support. PRP has been used successfully in orthopedics, sports medicine, dermatology, hair growth, and dentistry, among others.

Benefits of PRP treatments for accelerating wound healing

PRP treatment has shown promising results in various medical fields. It can accelerate the wound healing process, reduce pain and inflammation, and improve tissue function.

PRF: The Essential Information

What is PRF?

PRF, or Platelet-Rich Fibrin, is a second-generation platelet-rich therapy. Similar to PRP, it utilizes the patient's blood, but the processing method differs. PRF is an autologous blood product obtained by centrifuging the blood without anticoagulants, resulting in a fibrin clot that contains platelets.

What is the mechanism behind PRF?

PRF releases growth factors in a sustained manner, thanks to its fibrin matrix. This matrix acts as a three-dimensional support structure for cells, enhancing tissue healing. It provides a more natural and prolonged release of growth factors.

Benefits of PRF treatment for repairing tissues

PRF has been widely used in dentistry, oral and maxillofacial surgery, and plastic and

reconstructive surgery. It promotes soft tissue grafting, wound healing, bone healing, and

periodontal healing among other applications.

PRFM: The Essential Information

What is PRFM therapy?

PRFM, or Platelet-Rich Fibrin Matrix, takes platelet-rich therapies to the most advanced level. It combines the benefits of PRP and PRF, utilizing a matrix or scaffold-like substance to retain and maximize the platelet concentration and growth factors and eliminate red blood cells and white blood cells.

What is the science behind PRFM?

PRFM involves additional processing steps of PRF to create a spongy gel-like substance or fibrin matrix. This matrix provides a sustained release of growth factors and offers a supportive structure for cells, enhancing tissue healing.

Benefits of PRFM for healing and repairing tissues

PRFM has found applications in aesthetics, dermatology, and plastic surgery. It can be incorporated into facial treatments (vampire facials), reduce fine lines and wrinkles, and enhance wound healing and scar revision.

PRP, PRF, and PRFM: Similarities and Differences

Varying Generation Technologies

  • PRP: First generation

  • PRF: Second generation

  • PRFM: Ultimate generation

Similar Procedures with Slight Variations

  • All three therapies use autologous platelets, from the patient's own whole blood sample, minimizing side effects and risk of infection

  • All three therapies stimulate cell and collagen growth but in differing ways

  • They use different centrifugation parameters, for example, PRF uses a lower spin speed

  • All three therapies may use acid citrate in the test tubes as an anticoagulant to prevent blood clotting during the processing and preparation stages, enabling the separation and concentration of platelets.

  • All three therapies may use calcium chloride as an activator in PRP, PRF, and PRFM therapies to stimulate the release of growth factors from platelets.

PRP, PRF, and PRFM: Which is Better?

When it comes to choosing between PRP, PRF, and PRFM, there is no one-size-fits-all answer. The selection depends on the unique needs of each individual patient. While these platelet-rich therapies share similarities, understanding their differences is crucial for making an informed decision. Consulting a physician is essential in determining which treatment option will best suit your specific requirements. Here are some key points to consider:

  1. Individualized Approach: PRP, PRF, and PRFM offer tailored solution therapies, ensuring that the treatment aligns with your specific condition, desired outcomes, and medical history.

  2. Efficacy for Different Applications: Depending on the medical field and the condition being treated, one therapy may demonstrate superior efficacy compared to the others.

  3. Treatment Duration: The duration of treatment effects can vary. PRP therapy typically lasts for a few weeks, providing short to medium-term benefits. PRF therapy, on the other hand, may offer effects lasting several months. PRFM, with its enhanced scaffold-like matrix, tends to provide extended support for tissue repair, with prolonged release of healing factors.

  4. Consultation with a Physician: To determine the most suitable treatment option, it's essential to consult with a knowledgeable physician. They will thoroughly evaluate your condition, discuss your goals, and recommend the most appropriate treatment based on their expertise and experience.

  5. Personalized Treatment Plans: Physicians will develop personalized treatment plans that take into account factors such as the severity of the condition, location of the injury, and desired outcomes. This ensures that you receive the most effective and customized approach to maximize healing potential.

Remember, the key to making an informed decision between PRP, PRF, and PRFM lies in understanding your unique needs and seeking professional guidance. By working closely with a skilled physician, you can embark on a therapy that is tailored to your specific requirements, leading to optimal outcomes and a faster path to recovery.

Platelet Rich Plasma and Stem Cells

Many people have questions about the effect of PRP/PRF/PRFM on stem cells. Stem cells play a role in the context of PRP, PRF, and PRFM therapies, although they are not directly incorporated into these treatments.

PRP, PRF, and PRFM therapies primarily utilize platelets derived from the patient's own blood. Platelets contain growth factors that promote tissue healing. While these therapies do not introduce stem cells directly, the growth factors released by platelets can promote their activity.

So, while stem cells are not directly incorporated into PRP, PRF, or PRFM therapies, the growth factors released by platelets in these treatments can indirectly stimulate the body's natural stem cells and contribute to tissue healing.


Platelet-rich therapies such as PRP, PRF, and PRFM are superior treatment options to traditional therapies and have gained significant attention for their ability to heal tissue damage using the body's natural healing abilities with less trauma. There are key differences, however, so choosing a therapy will be done using a case-by-case approach.

PRP treatments, the original breakthrough, utilizes concentrated plasma rich in growth factors to stimulate tissue healing. PRF, a second-generation platelet concentrate therapy, releases growth factors in a sustained manner through a fibrin matrix, promoting tissue healing support PRFM, the most advanced therapy, combines the benefits of PRP and PRF by utilizing a spongy fibrin matrix to protect and retain concentrated platelets and growth factors. While these therapies share similarities, their concentrations, duration of effect, and applications differ.

Choosing the right therapy is done on a case-by-case basis and should be done in consultation with a knowledgeable physician. By understanding the unique benefits and seeking personalized treatment plans, patients can embark on a therapy journey tailored to their specific requirements, leading to optimal outcomes and a faster path to recovery.

Selphyl has the next-generation PRFM kits that you need to elevate your patients’ quality of life. Contact us with any questions!

79 views0 comments

Recent Posts

See All

PRF treatment has gained immense popularity in recent years due to its remarkable benefits. This revolutionary technique utilizes the patien

bottom of page